ParkinsonCanadaV1, Main, Exploration, bibRecord, 001513

Investigation of C9orf72 in 4 Neurodegenerative Disorders

Identifieur interne : 001513 ( Main/Exploration ); précédent : 001512; suivant : 001514

Investigation of C9orf72 in 4 Neurodegenerative Disorders

Auteurs : ZHENGRUI XI [Canada] ; Lome Zinman [Canada] ; Yakov Grinberg [Canada] ; Danielle Moreno ; Christine Sato [Canada] ; Juan M. Bilbao [Canada] ; Mahdi Ghani [Canada] ; Isabel Hernandez [Espagne] ; Agustín Ruiz [Espagne] ; Mercè Boada [Espagne] ; Francisco J. Moron [Canada, Espagne] ; Anthony E. Lang [Canada] ; Connie Marras [Canada] ; Amalia Bruni [Italie] ; Rosanna Colao [Italie] ; Raffaele G. Maletta [Italie] ; Gianfranco Puccio [Italie] ; Innocenzo Rainero [Italie] ; Lorenzo Pinessi [Italie] ; Daniela Galimberti [Italie] ; Karen E. Morrison [États-Unis] ; Catriona Moorby [États-Unis] ; Joanne D. Stockton [États-Unis] ; Mario Masellis [Canada] ; Sandra E. Black [Canada] ; Lili-Naz Hazrati [Canada] ; YAN LIANG [Canada] ; Jan Van Haersma De With [Canada] ; Luis Fornazzari [Canada] ; Roque Villagra [Chili] ; Ricardo Rojas-Garcia [Canada, Espagne] ; Jordi Clarimon [Espagne] ; Richard Mayeux [États-Unis] ; Janice Robertson [Canada] ; Peter St George-Hyslop [Canada, Royaume-Uni] ; Ekaterina Rogaeva [Canada]

Source :

Archives of neurology : (Chicago) [ 0003-9942 ] ; 2012.

RBID : Pascal:13-0318164

Descripteurs français

Pascal (Inist)
- Pathologie du système nerveux.

English descriptors

KwdEn :
- Nervous system diseases.

Abstract

Objective: To estimate the allele frequency of C9orf72 (G₄C₂) repeats in amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), Alzheimer disease (AD), and Parkinson disease (PD). Design: The number of repeats was estimated by a 2-step genotyping strategy. For expansion carriers, we sequenced the repeat flanking regions and obtained APOE genotypes and MAPT H1/H2 haplotypes. Setting: Hospitals specializing in neurodegenerative disorders. Subjects: We analyzed 520 patients with FTLD, 389 patients with ALS, 424 patients with AD, 289 patients with PD, 602 controls, 18 families, and 29 patients with PD with the LRRK2 G2019S mutation. Main Outcome Measure: The expansion frequency. Results: Based on a prior cutoff (>30 repeats), the expansion was detected in 9.3% of patients with ALS, 5.2% of patients with FTLD, and 0.7% of patients with PD but not in controls or patients with AD. It was significantly associated with family history of ALS or FTLD and age at onset of FTLD. Phenotype variation (ALS vs FTLD) was not associated with MAPT, APOE, or variability in the repeat flanking regions. Two patients with PD were carriers of 39 and 32 repeats with questionable pathological significance, since the 39-repeat allele does not segregate with PD. No expansion or intermediate alleles (20-29 repeats) were found among the G2019S carriers and AD cases with TAR DNA-binding protein 43- positive inclusions. Surprisingly, the frequency of the 10-repeat allele was marginally increased in all 4 neurodegenerative diseases compared with controls, indicating the presence of an unknown risk variation in the C9orf72 locus. Conclusions: The C9orf72 expansion is a common cause of ALS and FTLD, but not of AD or PD. Our study raises concern about a reliable cutoff for the pathological repeat number, which is important in the utility of genetic screening.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000070
to stream PascalFrancis, to step Curation: 000B63
to stream PascalFrancis, to step Checkpoint: 000146
to stream Main, to step Merge: 001560
to stream Main, to step Curation: 001513

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Investigation of C9orf72 in 4 Neurodegenerative Disorders</title>
<author><name sortKey="Zhengrui Xi" sort="Zhengrui Xi" uniqKey="Zhengrui Xi" last="Zhengrui Xi">ZHENGRUI XI</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zinman, Lome" sort="Zinman, Lome" uniqKey="Zinman L" first="Lome" last="Zinman">Lome Zinman</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>University of Toronto, Sunnybrook Health Sciences Centre</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grinberg, Yakov" sort="Grinberg, Yakov" uniqKey="Grinberg Y" first="Yakov" last="Grinberg">Yakov Grinberg</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moreno, Danielle" sort="Moreno, Danielle" uniqKey="Moreno D" first="Danielle" last="Moreno">Danielle Moreno</name>
</author>
<author><name sortKey="Sato, Christine" sort="Sato, Christine" uniqKey="Sato C" first="Christine" last="Sato">Christine Sato</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bilbao, Juan M" sort="Bilbao, Juan M" uniqKey="Bilbao J" first="Juan M." last="Bilbao">Juan M. Bilbao</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>University of Toronto, Sunnybrook Health Sciences Centre</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ghani, Mahdi" sort="Ghani, Mahdi" uniqKey="Ghani M" first="Mahdi" last="Ghani">Mahdi Ghani</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hernandez, Isabel" sort="Hernandez, Isabel" uniqKey="Hernandez I" first="Isabel" last="Hernandez">Isabel Hernandez</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades</s1>
<s3>ESP</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ruiz, Agustin" sort="Ruiz, Agustin" uniqKey="Ruiz A" first="Agustín" last="Ruiz">Agustín Ruiz</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades</s1>
<s3>ESP</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades</s1>
<s3>ESP</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Hospital Universitari Vail d'Hebron-Institut de Recerca, Universitat Autònoma de Barcelona (VHIR-UAB)</s1>
<s3>ESP</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
<orgName type="university">Université autonome de Barcelone</orgName>
</affiliation>
</author>
<author><name sortKey="Moron, Francisco J" sort="Moron, Francisco J" uniqKey="Moron F" first="Francisco J." last="Moron">Francisco J. Moron</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Structural Genomics</s1>
<s2>Neocodex, Seville</s2>
<s3>ESP</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Department of Structural Genomics</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Medicine</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Medicine</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bruni, Amalia" sort="Bruni, Amalia" uniqKey="Bruni A" first="Amalia" last="Bruni">Amalia Bruni</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Regional Neurogenetic Centre, Lamezia Terme, Azienda Sanitaria Provinciale Catanzaro</s1>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Regional Neurogenetic Centre, Lamezia Terme, Azienda Sanitaria Provinciale Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Colao, Rosanna" sort="Colao, Rosanna" uniqKey="Colao R" first="Rosanna" last="Colao">Rosanna Colao</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Regional Neurogenetic Centre, Lamezia Terme, Azienda Sanitaria Provinciale Catanzaro</s1>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Regional Neurogenetic Centre, Lamezia Terme, Azienda Sanitaria Provinciale Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maletta, Raffaele G" sort="Maletta, Raffaele G" uniqKey="Maletta R" first="Raffaele G." last="Maletta">Raffaele G. Maletta</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Regional Neurogenetic Centre, Lamezia Terme, Azienda Sanitaria Provinciale Catanzaro</s1>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Regional Neurogenetic Centre, Lamezia Terme, Azienda Sanitaria Provinciale Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Puccio, Gianfranco" sort="Puccio, Gianfranco" uniqKey="Puccio G" first="Gianfranco" last="Puccio">Gianfranco Puccio</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Regional Neurogenetic Centre, Lamezia Terme, Azienda Sanitaria Provinciale Catanzaro</s1>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Regional Neurogenetic Centre, Lamezia Terme, Azienda Sanitaria Provinciale Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rainero, Innocenzo" sort="Rainero, Innocenzo" uniqKey="Rainero I" first="Innocenzo" last="Rainero">Innocenzo Rainero</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Neurology II, Department of Neuro-science, University of Torino</s1>
<s2>Turin</s2>
<s3>ITA</s3>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pinessi, Lorenzo" sort="Pinessi, Lorenzo" uniqKey="Pinessi L" first="Lorenzo" last="Pinessi">Lorenzo Pinessi</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Neurology II, Department of Neuro-science, University of Torino</s1>
<s2>Turin</s2>
<s3>ITA</s3>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Neurological Sciences, University of Milan, Centro Dino Ferrari, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morrison, Karen E" sort="Morrison, Karen E" uniqKey="Morrison K" first="Karen E." last="Morrison">Karen E. Morrison</name>
<affiliation wicri:level="4"><inist:fA14 i1="15"><s1>School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham</s1>
<s2>Birmingham</s2>
<s3>USA</s3>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
<settlement type="city">Birmingham</settlement>
</placeName>
<orgName type="university">Université de Birmingham</orgName>
</affiliation>
</author>
<author><name sortKey="Moorby, Catriona" sort="Moorby, Catriona" uniqKey="Moorby C" first="Catriona" last="Moorby">Catriona Moorby</name>
<affiliation wicri:level="4"><inist:fA14 i1="15"><s1>School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham</s1>
<s2>Birmingham</s2>
<s3>USA</s3>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
<settlement type="city">Birmingham</settlement>
</placeName>
<orgName type="university">Université de Birmingham</orgName>
</affiliation>
</author>
<author><name sortKey="Stockton, Joanne D" sort="Stockton, Joanne D" uniqKey="Stockton J" first="Joanne D." last="Stockton">Joanne D. Stockton</name>
<affiliation wicri:level="4"><inist:fA14 i1="15"><s1>School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham</s1>
<s2>Birmingham</s2>
<s3>USA</s3>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
<settlement type="city">Birmingham</settlement>
</placeName>
<orgName type="university">Université de Birmingham</orgName>
</affiliation>
</author>
<author><name sortKey="Masellis, Mario" sort="Masellis, Mario" uniqKey="Masellis M" first="Mario" last="Masellis">Mario Masellis</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Medicine</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>University of Toronto, Sunnybrook Health Sciences Centre</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Black, Sandra E" sort="Black, Sandra E" uniqKey="Black S" first="Sandra E." last="Black">Sandra E. Black</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Medicine</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hazrati, Lili Naz" sort="Hazrati, Lili Naz" uniqKey="Hazrati L" first="Lili-Naz" last="Hazrati">Lili-Naz Hazrati</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yan Liang" sort="Yan Liang" uniqKey="Yan Liang" last="Yan Liang">YAN LIANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Haersma De With, Jan" sort="Van Haersma De With, Jan" uniqKey="Van Haersma De With J" first="Jan" last="Van Haersma De With">Jan Van Haersma De With</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fornazzari, Luis" sort="Fornazzari, Luis" uniqKey="Fornazzari L" first="Luis" last="Fornazzari">Luis Fornazzari</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, St. Michael's Hospital</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Villagra, Roque" sort="Villagra, Roque" uniqKey="Villagra R" first="Roque" last="Villagra">Roque Villagra</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Salvador Hospital, University of Chile</s1>
<s2>Santiago</s2>
<s3>CHL</s3>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Chili</country>
<wicri:noRegion>Santiago</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rojas Garcia, Ricardo" sort="Rojas Garcia, Ricardo" uniqKey="Rojas Garcia R" first="Ricardo" last="Rojas-Garcia">Ricardo Rojas-Garcia</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Neurology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
<settlement type="city">Barcelone</settlement>
</placeName>
<orgName type="university">Université autonome de Barcelone</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED)</s1>
<s2>Madrid</s2>
<s3>ESP</s3>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name>
<affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Neurology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
<settlement type="city">Barcelone</settlement>
</placeName>
<orgName type="university">Université autonome de Barcelone</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED)</s1>
<s2>Madrid</s2>
<s3>ESP</s3>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<affiliation wicri:level="4"><inist:fA14 i1="18"><s1>The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Departments of Neurology, Psychiatry, Columbia University</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="19"><s1>Medicine, College of Physicians and Surgeons, Columbia University</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Robertson, Janice" sort="Robertson, Janice" uniqKey="Robertson J" first="Janice" last="Robertson">Janice Robertson</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="St George Hyslop, Peter" sort="St George Hyslop, Peter" uniqKey="St George Hyslop P" first="Peter" last="St George-Hyslop">Peter St George-Hyslop</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Medicine</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="16"><s1>Cambridge Institute for Medical Research and the Department of Clinical Neurosciences, University of Cambridge</s1>
<s2>Cambridge, England</s2>
<s3>GBR</s3>
<sZ>35 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
<orgName type="university">Université de Cambridge</orgName>
</affiliation>
</author>
<author><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Medicine</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">13-0318164</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 13-0318164 INIST</idno>
<idno type="RBID">Pascal:13-0318164</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000070</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000B63</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000146</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000146</idno>
<idno type="wicri:doubleKey">0003-9942:2012:Zhengrui Xi:investigation:of:c</idno>
<idno type="wicri:Area/Main/Merge">001560</idno>
<idno type="wicri:Area/Main/Curation">001513</idno>
<idno type="wicri:Area/Main/Exploration">001513</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Investigation of C9orf72 in 4 Neurodegenerative Disorders</title>
<author><name sortKey="Zhengrui Xi" sort="Zhengrui Xi" uniqKey="Zhengrui Xi" last="Zhengrui Xi">ZHENGRUI XI</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zinman, Lome" sort="Zinman, Lome" uniqKey="Zinman L" first="Lome" last="Zinman">Lome Zinman</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>University of Toronto, Sunnybrook Health Sciences Centre</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grinberg, Yakov" sort="Grinberg, Yakov" uniqKey="Grinberg Y" first="Yakov" last="Grinberg">Yakov Grinberg</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moreno, Danielle" sort="Moreno, Danielle" uniqKey="Moreno D" first="Danielle" last="Moreno">Danielle Moreno</name>
</author>
<author><name sortKey="Sato, Christine" sort="Sato, Christine" uniqKey="Sato C" first="Christine" last="Sato">Christine Sato</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bilbao, Juan M" sort="Bilbao, Juan M" uniqKey="Bilbao J" first="Juan M." last="Bilbao">Juan M. Bilbao</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>University of Toronto, Sunnybrook Health Sciences Centre</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ghani, Mahdi" sort="Ghani, Mahdi" uniqKey="Ghani M" first="Mahdi" last="Ghani">Mahdi Ghani</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hernandez, Isabel" sort="Hernandez, Isabel" uniqKey="Hernandez I" first="Isabel" last="Hernandez">Isabel Hernandez</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades</s1>
<s3>ESP</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ruiz, Agustin" sort="Ruiz, Agustin" uniqKey="Ruiz A" first="Agustín" last="Ruiz">Agustín Ruiz</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades</s1>
<s3>ESP</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades</s1>
<s3>ESP</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Hospital Universitari Vail d'Hebron-Institut de Recerca, Universitat Autònoma de Barcelona (VHIR-UAB)</s1>
<s3>ESP</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
<orgName type="university">Université autonome de Barcelone</orgName>
</affiliation>
</author>
<author><name sortKey="Moron, Francisco J" sort="Moron, Francisco J" uniqKey="Moron F" first="Francisco J." last="Moron">Francisco J. Moron</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Structural Genomics</s1>
<s2>Neocodex, Seville</s2>
<s3>ESP</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Department of Structural Genomics</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Medicine</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Medicine</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bruni, Amalia" sort="Bruni, Amalia" uniqKey="Bruni A" first="Amalia" last="Bruni">Amalia Bruni</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Regional Neurogenetic Centre, Lamezia Terme, Azienda Sanitaria Provinciale Catanzaro</s1>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Regional Neurogenetic Centre, Lamezia Terme, Azienda Sanitaria Provinciale Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Colao, Rosanna" sort="Colao, Rosanna" uniqKey="Colao R" first="Rosanna" last="Colao">Rosanna Colao</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Regional Neurogenetic Centre, Lamezia Terme, Azienda Sanitaria Provinciale Catanzaro</s1>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Regional Neurogenetic Centre, Lamezia Terme, Azienda Sanitaria Provinciale Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maletta, Raffaele G" sort="Maletta, Raffaele G" uniqKey="Maletta R" first="Raffaele G." last="Maletta">Raffaele G. Maletta</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Regional Neurogenetic Centre, Lamezia Terme, Azienda Sanitaria Provinciale Catanzaro</s1>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Regional Neurogenetic Centre, Lamezia Terme, Azienda Sanitaria Provinciale Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Puccio, Gianfranco" sort="Puccio, Gianfranco" uniqKey="Puccio G" first="Gianfranco" last="Puccio">Gianfranco Puccio</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Regional Neurogenetic Centre, Lamezia Terme, Azienda Sanitaria Provinciale Catanzaro</s1>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Regional Neurogenetic Centre, Lamezia Terme, Azienda Sanitaria Provinciale Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rainero, Innocenzo" sort="Rainero, Innocenzo" uniqKey="Rainero I" first="Innocenzo" last="Rainero">Innocenzo Rainero</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Neurology II, Department of Neuro-science, University of Torino</s1>
<s2>Turin</s2>
<s3>ITA</s3>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pinessi, Lorenzo" sort="Pinessi, Lorenzo" uniqKey="Pinessi L" first="Lorenzo" last="Pinessi">Lorenzo Pinessi</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Neurology II, Department of Neuro-science, University of Torino</s1>
<s2>Turin</s2>
<s3>ITA</s3>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Neurological Sciences, University of Milan, Centro Dino Ferrari, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morrison, Karen E" sort="Morrison, Karen E" uniqKey="Morrison K" first="Karen E." last="Morrison">Karen E. Morrison</name>
<affiliation wicri:level="4"><inist:fA14 i1="15"><s1>School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham</s1>
<s2>Birmingham</s2>
<s3>USA</s3>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
<settlement type="city">Birmingham</settlement>
</placeName>
<orgName type="university">Université de Birmingham</orgName>
</affiliation>
</author>
<author><name sortKey="Moorby, Catriona" sort="Moorby, Catriona" uniqKey="Moorby C" first="Catriona" last="Moorby">Catriona Moorby</name>
<affiliation wicri:level="4"><inist:fA14 i1="15"><s1>School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham</s1>
<s2>Birmingham</s2>
<s3>USA</s3>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
<settlement type="city">Birmingham</settlement>
</placeName>
<orgName type="university">Université de Birmingham</orgName>
</affiliation>
</author>
<author><name sortKey="Stockton, Joanne D" sort="Stockton, Joanne D" uniqKey="Stockton J" first="Joanne D." last="Stockton">Joanne D. Stockton</name>
<affiliation wicri:level="4"><inist:fA14 i1="15"><s1>School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham</s1>
<s2>Birmingham</s2>
<s3>USA</s3>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
<settlement type="city">Birmingham</settlement>
</placeName>
<orgName type="university">Université de Birmingham</orgName>
</affiliation>
</author>
<author><name sortKey="Masellis, Mario" sort="Masellis, Mario" uniqKey="Masellis M" first="Mario" last="Masellis">Mario Masellis</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Medicine</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>University of Toronto, Sunnybrook Health Sciences Centre</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Black, Sandra E" sort="Black, Sandra E" uniqKey="Black S" first="Sandra E." last="Black">Sandra E. Black</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Medicine</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hazrati, Lili Naz" sort="Hazrati, Lili Naz" uniqKey="Hazrati L" first="Lili-Naz" last="Hazrati">Lili-Naz Hazrati</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yan Liang" sort="Yan Liang" uniqKey="Yan Liang" last="Yan Liang">YAN LIANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Haersma De With, Jan" sort="Van Haersma De With, Jan" uniqKey="Van Haersma De With J" first="Jan" last="Van Haersma De With">Jan Van Haersma De With</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fornazzari, Luis" sort="Fornazzari, Luis" uniqKey="Fornazzari L" first="Luis" last="Fornazzari">Luis Fornazzari</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, St. Michael's Hospital</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Villagra, Roque" sort="Villagra, Roque" uniqKey="Villagra R" first="Roque" last="Villagra">Roque Villagra</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Salvador Hospital, University of Chile</s1>
<s2>Santiago</s2>
<s3>CHL</s3>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Chili</country>
<wicri:noRegion>Santiago</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rojas Garcia, Ricardo" sort="Rojas Garcia, Ricardo" uniqKey="Rojas Garcia R" first="Ricardo" last="Rojas-Garcia">Ricardo Rojas-Garcia</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Neurology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
<settlement type="city">Barcelone</settlement>
</placeName>
<orgName type="university">Université autonome de Barcelone</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED)</s1>
<s2>Madrid</s2>
<s3>ESP</s3>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name>
<affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Neurology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
<settlement type="city">Barcelone</settlement>
</placeName>
<orgName type="university">Université autonome de Barcelone</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED)</s1>
<s2>Madrid</s2>
<s3>ESP</s3>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<affiliation wicri:level="4"><inist:fA14 i1="18"><s1>The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Departments of Neurology, Psychiatry, Columbia University</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="19"><s1>Medicine, College of Physicians and Surgeons, Columbia University</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Robertson, Janice" sort="Robertson, Janice" uniqKey="Robertson J" first="Janice" last="Robertson">Janice Robertson</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="St George Hyslop, Peter" sort="St George Hyslop, Peter" uniqKey="St George Hyslop P" first="Peter" last="St George-Hyslop">Peter St George-Hyslop</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Medicine</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="16"><s1>Cambridge Institute for Medical Research and the Department of Clinical Neurosciences, University of Cambridge</s1>
<s2>Cambridge, England</s2>
<s3>GBR</s3>
<sZ>35 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
<orgName type="university">Université de Cambridge</orgName>
</affiliation>
</author>
<author><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Tanz Centre for Research in Neurodegenerative Diseases</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Tanz Centre for Research in Neurodegenerative Diseases</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Medicine</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Archives of neurology : (Chicago)</title>
<title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title>
<idno type="ISSN">0003-9942</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Archives of neurology : (Chicago)</title>
<title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title>
<idno type="ISSN">0003-9942</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du   système nerveux</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective: To estimate the allele frequency of C9orf72 (G<sub>4</sub>
C<sub>2</sub>
) repeats in amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), Alzheimer disease (AD), and Parkinson disease (PD). Design: The number of repeats was estimated by a 2-step genotyping strategy. For expansion carriers, we sequenced the repeat flanking regions and obtained APOE genotypes and MAPT H1/H2 haplotypes. Setting: Hospitals specializing in neurodegenerative disorders. Subjects: We analyzed 520 patients with FTLD, 389 patients with ALS, 424 patients with AD, 289 patients with PD, 602 controls, 18 families, and 29 patients with PD with the LRRK2 G2019S mutation. Main Outcome Measure: The expansion frequency. Results: Based on a prior cutoff (>30 repeats), the expansion was detected in 9.3% of patients with ALS, 5.2% of patients with FTLD, and 0.7% of patients with PD but not in controls or patients with AD. It was significantly associated with family history of ALS or FTLD and age at onset of FTLD. Phenotype variation (ALS vs FTLD) was not associated with MAPT, APOE, or variability in the repeat flanking regions. Two patients with PD were carriers of 39 and 32 repeats with questionable pathological significance, since the 39-repeat allele does not segregate with PD. No expansion or intermediate alleles (20-29 repeats) were found among the G2019S carriers and AD cases with TAR DNA-binding protein 43- positive inclusions. Surprisingly, the frequency of the 10-repeat allele was marginally increased in all 4 neurodegenerative diseases compared with controls, indicating the presence of an unknown risk variation in the C9orf72 locus. Conclusions: The C9orf72 expansion is a common cause of ALS and FTLD, but not of AD or PD. Our study raises concern about a reliable cutoff for the pathological repeat number, which is important in the utility of genetic screening.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>Chili</li>
<li>Espagne</li>
<li>Italie</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Catalogne</li>
<li>Communauté de Madrid</li>
<li>Lombardie</li>
<li>Midlands de l'Ouest</li>
<li>Ontario</li>
<li>Piémont</li>
<li>État de New York</li>
</region>
<settlement><li>Barcelone</li>
<li>Birmingham</li>
<li>Cambridge</li>
<li>Madrid</li>
<li>Milan</li>
<li>New York</li>
<li>Toronto</li>
<li>Turin</li>
</settlement>
<orgName><li>Université Columbia</li>
<li>Université autonome de Barcelone</li>
<li>Université de Birmingham</li>
<li>Université de Cambridge</li>
<li>Université de Toronto</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Moreno, Danielle" sort="Moreno, Danielle" uniqKey="Moreno D" first="Danielle" last="Moreno">Danielle Moreno</name>
</noCountry>
<country name="Canada"><noRegion><name sortKey="Zhengrui Xi" sort="Zhengrui Xi" uniqKey="Zhengrui Xi" last="Zhengrui Xi">ZHENGRUI XI</name>
</noRegion>
<name sortKey="Bilbao, Juan M" sort="Bilbao, Juan M" uniqKey="Bilbao J" first="Juan M." last="Bilbao">Juan M. Bilbao</name>
<name sortKey="Black, Sandra E" sort="Black, Sandra E" uniqKey="Black S" first="Sandra E." last="Black">Sandra E. Black</name>
<name sortKey="Black, Sandra E" sort="Black, Sandra E" uniqKey="Black S" first="Sandra E." last="Black">Sandra E. Black</name>
<name sortKey="Fornazzari, Luis" sort="Fornazzari, Luis" uniqKey="Fornazzari L" first="Luis" last="Fornazzari">Luis Fornazzari</name>
<name sortKey="Ghani, Mahdi" sort="Ghani, Mahdi" uniqKey="Ghani M" first="Mahdi" last="Ghani">Mahdi Ghani</name>
<name sortKey="Grinberg, Yakov" sort="Grinberg, Yakov" uniqKey="Grinberg Y" first="Yakov" last="Grinberg">Yakov Grinberg</name>
<name sortKey="Hazrati, Lili Naz" sort="Hazrati, Lili Naz" uniqKey="Hazrati L" first="Lili-Naz" last="Hazrati">Lili-Naz Hazrati</name>
<name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name>
<name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name>
<name sortKey="Masellis, Mario" sort="Masellis, Mario" uniqKey="Masellis M" first="Mario" last="Masellis">Mario Masellis</name>
<name sortKey="Masellis, Mario" sort="Masellis, Mario" uniqKey="Masellis M" first="Mario" last="Masellis">Mario Masellis</name>
<name sortKey="Masellis, Mario" sort="Masellis, Mario" uniqKey="Masellis M" first="Mario" last="Masellis">Mario Masellis</name>
<name sortKey="Moron, Francisco J" sort="Moron, Francisco J" uniqKey="Moron F" first="Francisco J." last="Moron">Francisco J. Moron</name>
<name sortKey="Robertson, Janice" sort="Robertson, Janice" uniqKey="Robertson J" first="Janice" last="Robertson">Janice Robertson</name>
<name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name>
<name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name>
<name sortKey="Rojas Garcia, Ricardo" sort="Rojas Garcia, Ricardo" uniqKey="Rojas Garcia R" first="Ricardo" last="Rojas-Garcia">Ricardo Rojas-Garcia</name>
<name sortKey="Sato, Christine" sort="Sato, Christine" uniqKey="Sato C" first="Christine" last="Sato">Christine Sato</name>
<name sortKey="St George Hyslop, Peter" sort="St George Hyslop, Peter" uniqKey="St George Hyslop P" first="Peter" last="St George-Hyslop">Peter St George-Hyslop</name>
<name sortKey="St George Hyslop, Peter" sort="St George Hyslop, Peter" uniqKey="St George Hyslop P" first="Peter" last="St George-Hyslop">Peter St George-Hyslop</name>
<name sortKey="Van Haersma De With, Jan" sort="Van Haersma De With, Jan" uniqKey="Van Haersma De With J" first="Jan" last="Van Haersma De With">Jan Van Haersma De With</name>
<name sortKey="Yan Liang" sort="Yan Liang" uniqKey="Yan Liang" last="Yan Liang">YAN LIANG</name>
<name sortKey="Zinman, Lome" sort="Zinman, Lome" uniqKey="Zinman L" first="Lome" last="Zinman">Lome Zinman</name>
</country>
<country name="Espagne"><noRegion><name sortKey="Hernandez, Isabel" sort="Hernandez, Isabel" uniqKey="Hernandez I" first="Isabel" last="Hernandez">Isabel Hernandez</name>
</noRegion>
<name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name>
<name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name>
<name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name>
<name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name>
<name sortKey="Moron, Francisco J" sort="Moron, Francisco J" uniqKey="Moron F" first="Francisco J." last="Moron">Francisco J. Moron</name>
<name sortKey="Rojas Garcia, Ricardo" sort="Rojas Garcia, Ricardo" uniqKey="Rojas Garcia R" first="Ricardo" last="Rojas-Garcia">Ricardo Rojas-Garcia</name>
<name sortKey="Rojas Garcia, Ricardo" sort="Rojas Garcia, Ricardo" uniqKey="Rojas Garcia R" first="Ricardo" last="Rojas-Garcia">Ricardo Rojas-Garcia</name>
<name sortKey="Ruiz, Agustin" sort="Ruiz, Agustin" uniqKey="Ruiz A" first="Agustín" last="Ruiz">Agustín Ruiz</name>
</country>
<country name="Italie"><noRegion><name sortKey="Bruni, Amalia" sort="Bruni, Amalia" uniqKey="Bruni A" first="Amalia" last="Bruni">Amalia Bruni</name>
</noRegion>
<name sortKey="Colao, Rosanna" sort="Colao, Rosanna" uniqKey="Colao R" first="Rosanna" last="Colao">Rosanna Colao</name>
<name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name>
<name sortKey="Maletta, Raffaele G" sort="Maletta, Raffaele G" uniqKey="Maletta R" first="Raffaele G." last="Maletta">Raffaele G. Maletta</name>
<name sortKey="Pinessi, Lorenzo" sort="Pinessi, Lorenzo" uniqKey="Pinessi L" first="Lorenzo" last="Pinessi">Lorenzo Pinessi</name>
<name sortKey="Puccio, Gianfranco" sort="Puccio, Gianfranco" uniqKey="Puccio G" first="Gianfranco" last="Puccio">Gianfranco Puccio</name>
<name sortKey="Rainero, Innocenzo" sort="Rainero, Innocenzo" uniqKey="Rainero I" first="Innocenzo" last="Rainero">Innocenzo Rainero</name>
</country>
<country name="États-Unis"><region name="Angleterre"><name sortKey="Morrison, Karen E" sort="Morrison, Karen E" uniqKey="Morrison K" first="Karen E." last="Morrison">Karen E. Morrison</name>
</region>
<name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<name sortKey="Moorby, Catriona" sort="Moorby, Catriona" uniqKey="Moorby C" first="Catriona" last="Moorby">Catriona Moorby</name>
<name sortKey="Stockton, Joanne D" sort="Stockton, Joanne D" uniqKey="Stockton J" first="Joanne D." last="Stockton">Joanne D. Stockton</name>
</country>
<country name="Chili"><noRegion><name sortKey="Villagra, Roque" sort="Villagra, Roque" uniqKey="Villagra R" first="Roque" last="Villagra">Roque Villagra</name>
</noRegion>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="St George Hyslop, Peter" sort="St George Hyslop, Peter" uniqKey="St George Hyslop P" first="Peter" last="St George-Hyslop">Peter St George-Hyslop</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001513 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001513 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:13-0318164
   |texte=   Investigation of C9orf72 in 4 Neurodegenerative Disorders
}}

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Investigation of C9orf72 in 4 Neurodegenerative Disorders

Investigation of C9orf72 in 4 Neurodegenerative Disorders

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri